Colon cancer: it's CIN or CIMP.
نویسنده
چکیده
Combined genetic and epigenetic analysis of sporadic colon cancer suggest that it can no longer be viewed as a single disease. There are at least three different subsets with distinct clinico-pathologic features, with important implications for preventions, screening, and therapy.
منابع مشابه
CpG island methylator phenotype associates with low-degree chromosomal abnormalities in colorectal cancer.
PURPOSE Aberrant promoter methylation and genomic instability occur frequently during colorectal cancer development. CpG island methylator phenotype (CIMP) has been shown to associate with microsatellite instability, and BRAF mutation and is often found in the right-side colon. Nevertheless, the relative importance of CIMP and chromosomal instability (CIN) for tumorigenesis has yet to be thorou...
متن کاملPrognostic Significance of CpG Island Methylator Phenotype in Colorectal Cancer
which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Colorectal cancer (CRC) is one of the major causes of cancer-related morbidity and mortality worldwide. Despite of recent advances of variable therapeutic techniques in CRC, cancer progression and metastasis remain the major contributors to cancer-related mo...
متن کاملHypermethylator phenotype in sporadic colon cancer: study on a population-based series of 582 cases.
The CpG island methylator phenotype (CIMP) is a distinct phenotype in colorectal cancer, associated with specific clinical, pathologic, and molecular features. However, most of the studies stratified methylation according to two subgroups (CIMP-High versus No-CIMP/CIMP-Low). In our study, we defined three different subgroups of methylation (No-CIMP, CIMP-Low, and CIMP-High) and evaluated the pr...
متن کاملThe Role of the CpG Island Methylator Phenotype on Survival Outcome in Colon Cancer
BACKGROUND/AIMS CpG island methylator phenotype (CIMP)- high colorectal cancers (CRCs) have distinct clinicopathologi-cal features from their CIMP-low/negative CRC counterparts. However, controversy exists regarding the prognosis of CRC according to the CIMP status. Therefore, this study examined the prognosis of Korean patients with colon cancer according to the CIMP status. METHODS Among a ...
متن کاملB Vitamins, Methionine and Alcohol Intake and Risk of Colon Cancer in Relation to BRAF Mutation and CpG Island Methylator Phenotype (CIMP)
BACKGROUND One-carbon metabolism appears to play an important role in DNA methylation reaction. Evidence suggests that a low intake of B vitamins or high alcohol consumption increases colorectal cancer risk. How one-carbon nutrients affect the CpG island methylator phenotype (CIMP) or BRAF mutation status in colon cancer remains uncertain. METHODS Utilizing incident colon cancers in a large p...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Clinical cancer research : an official journal of the American Association for Cancer Research
دوره 14 19 شماره
صفحات -
تاریخ انتشار 2008